Endocrine Abstracts

Background: Subclinical Cushing’s syndrome (SCS) due to incidentally discovered adrenal adenomas (AI) has been associated with increased prevalence of hypertension, obesity, and impaired glucose tolerance which are established risk factors for cardiovascular morbidity. Although functional and morphological (structural) changes of endothelium have been correlated with cardiovascular morbidity this has not been looked into detail in patients with adrenal incidentalomas....

Background: The renin-angiotensin system is important for blood pressure control. Screening and diagnostic tests used so far to diagnose patients with aldosterone related hypertension does not take into consideration the stimulating ACTH effect on aldosterone secretion.Objective: To assess the role of aldosterone in essential hypertension using a modified suppression test, performed under suppressed ACTH levels.Subjects and methods...

Introduction: Approximately 90% of the hypertensive population is characterized as having essential hypertension. Apart from renin and K+, ACTH plays an important role in aldosterone secretion, being a potent stimulant under situations of stress. Up to date, the association between stress and aldosterone-related hypertension has not been studied and that is the aim of our study.Methods: 36 hypertensive patients and 14 matched for age and sex c...

Background: The normal cut-offs of screening and diagnostic tests for autonomous aldosterone (AAS) and cortisol (ACS) secretion are poorly defined, mainly due to the presence of adrenal adenomas among those who have served as controls and the stimulating effect of ACTH on aldosterone secretion.Methods: We investigated cortisol and aldosterone secretion in 151 patients with benign cortical adrenal adenomas (BCAA) and in 119 healthy controls with a normal ...